Page 2 - Roche Hemlibra Non-inhibitors - Product Monograph
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TABLE OF CONTENTS








                  1. Overview of hemophilia A                                                    01


                  2. Clinical features of hemophilia A                                           01

                  3. Disease burden                                                              02

                      3.1. Humanistic burden                                                     02

                      3.2. Caregiver burden                                                      04

                      3.3. Economic burden                                                       05


                  4. Clinical management of the disease or health condition                      07

                      4.1. Unmet medical need                                                    07

                  5. Standard-of-care: Prophylaxis vs on-demand treatment for hemophilia A       12


                  6. Overview of HEMLIBRA ®                                                      15

                  7. Clinical effectiveness, efficacy, and safety of HEMLIBRA ®                     16

                      7.1. Efficacy of HEMLIBRA ®                                                  17

                      7.2. Safety of HEMLIBRA ®                                                  24

                      7.3. Quality of life with HEMLIBRA ®                                       26


                  8. Administration and dosing of HEMLIBRA ®                                     29

                  9. Take home messages                                                          29
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